Wythe County is a county located in the southwestern part of the U.S. state of Virginia. As of the 2020 census, the population was 28,290. Its county seat is Wytheville.

Cities: Wytheville, Rural Retreat, Max Meadows, Fort Chiswell, Austinville, Barren Springs
Population: 28,111 (2022)
District code: 5104110 ed.gov
Congressional district: 9th
Largest town: Wytheville
Named for: George Wythe